Michelle teplensky northwestern. T. DOI: 10. , Meckes, B. Michelle [2014] was chosen for STEM for BRITAIN which aims to encourage, support and promote Britain's early-stage and early-career research scientists, engineers, technologists and “What makes this vaccine different than other vaccines is the approach we take to design them,” said Dr. Mar 22, 2022 · More information: Michelle H. Teplensky, Michelle H. Distler, Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States. Lurie Comprehensive Cancer Center of Northwestern University at Northwestern Memorial Hospital. Jan 30, 2023 · “A challenge with conventional vaccines is that out of that blended mish mosh, an immune cell might pick up 50 antigens and one adjuvant or one antigen and 50 adjuvants,” said study author and former Northwestern postdoctoral associate Michelle Teplensky, PhD, who is now an assistant professor at Boston University. ,Mirkin a b, c 2, chadnano@northwestern. May 28, 2020 · Northwestern University Michelle Teplensky is a researcher developing innovative nanomedicine to treat prostate and breast cancer under support from the National Institutes of Health and This project was also supported by the Prostate Cancer Foundation and the Movember Foundation under award 17CHAL08, Convergence Science Medicine Institute seed award, and the Polsky Urologic Cancer Institute of the Robert H. The Jan 30, 2023 · A new way to significantly increase the potency of almost any vaccine has been developed by researchers from the International Institute for Nanotechnology at Northwestern. Dean Campbell (Professor) California Polytechnic State University. and one adjuvant or one antigen and 50 adjuvants,” said study author and former Northwestern postdoctoral associate Michelle Teplensky, who is now an assistant Sep 8, 2021 · Michelle H. Mar 22, 2022 · “What makes this vaccine different than other vaccines is the approach we take to design them,” said Dr. Nov 11, 2021 · Kacper Skakuj, † Michelle H. , Chen, C. Dittmar, Lei Qin, Shuya Wang, This work made use of the IMSERC MS facility at Northwestern University, with special thanks to Mr . Ezra connects with others in the immunoengineering field at his first conference as a graduate student! The Teplensky lab socializes with other attending BU labs (Pratt & O'Shea) at a group dinner. Mar 21, 2022 · Michelle H. Teplensky, Marcus Fantham, Peng Li, Timothy C. See full list on news. } and Jodrell, {Duncan I. Distler, a , b , 1 Caroline D. Dr. Sinegra, Shuya Wang, Chad A. Dittmar, Lei Qin, Shuya Wang, Michael Evangelopoulos, Bin Zhang, Chad A. Congratulations Yuwei. Sara Rupich, Dr. 1073/pnas. The stability of the core can significantly impact the therapeutic effectiveness of liposome-based drugs. Teplensky et al, Spherical nucleic acids as an infectious disease vaccine platform, Proceedings of the National Academy of Sciences (2022). IL Country . My research focuses on the development of a nanomaterial called spherical nucleic acids (SNAs) as a prostate cancer immunotherapy. } and Marcus Fantham and Chetan Poudel and Colin Hockings and Meng Lu and Alina Guna and Marta Aragones-Anglada and Moghadam, {Peyman Z. Teplensky. Feb 4, 2023 · “A challenge with conventional vaccines is that out of that blended mish mosh, an immune cell might pick up 50 antigens and one adjuvant or one antigen and 50 adjuvants,” said study author Assistant Professor Michelle Teplensky. Jan 30, 2023 · These authors contributed equally: Michelle H. } and Distler, {Max E. Controlling Intracellular Machinery via Polymer Pen Lithography Molecular Patterning. , Teplensky, M. Ph. Edmund Cheng for their support, friendship and positivity throughout. edu Aug 17, 2020 · My name is Michelle Teplensky and I am a postdoctoral fellow in the department of Chemistry at Northwestern University in the lab of Prof. Michelle Teplensky (Assistant Professor) Bradley University. H. Northwestern postdoctoral associate Michelle Teplensky, who is now an assistant professor at Boston University. "But there must be an Cancer vaccine structure is emerging as an important design factor that offers tunable parameters to enhance the targeted immune response. Jan 31, 2023 · Northwestern University . ACS Mar 13, 2018 · Michelle Teplensky has won the Silver Award at STEM for BRITAIN. Teplensky, Michael Evangelopoulos, Jasper W. northwestern. }", Jan 30, 2023 · “A challenge with conventional vaccines is that out of that blended mish mosh, an immune cell might pick up 50 antigens and one adjuvant or one antigen and 50 adjuvants,” said study author and former Northwestern postdoctoral associate Michelle Teplensky, who is now an assistant professor at Boston University. Teplensky, Michael Evangelopoulos. A. ” Mar 23, 2022 · And with minor changes, Northwestern University investigators hope the same vaccine platform could target other infectious diseases. Zack Urbach and Dr. Mirkin * * Corresponding author for this work Lin, M. , & Mirkin, C. Benjamin Tang. Tanushri Sengupta, Dr. “Even as recently as a few years ago people focused on selecting the right target to train the immune system and the right stimulant to activate it, not on how those components were Jan 1, 2023 · This material is based upon work supported by the Polsky Urologic Cancer Institute of the Robert H. 6 Rising Star Chemical Engineering 2020 Aisulu Aitbekova Stanford Nanomaterials to Program the Immune System The Teplensky lab brings together techniques across chemistry, nanotechnology, engineering, immunology, and biomaterials to impact how we architect the immune system through chemically-informed platforms. Authors and Affiliations Department of Chemistry and International Institute for Nanotechnology, Northwestern Semantic Scholar profile for Michelle H. Young, Peyman Z. 2119093119 Jan 30, 2023 · “Out of that blended mish-mosh, an immune cell might pick up 50 antigens and one adjuvant or one antigen and 50 adjuvants,” Michelle Teplensky, a former Northwestern postdoctoral associate and Research in the Teplensky Lab focuses on engineering nanotechnology to control immunological cell connectivity, processing, and communication by design. Farha, Clemens F author = "Teplensky, {Michelle H. S. Dittmar, § and Chad A. Verified email at bu. Northwestern University Feinberg School of Medicine. Peter Schwartz (Professor) Carnegie Mellon University. Moghadam, Joseph T. Rongchao Jin (Professor) Catalan Institute of Nanoscience and Nanotechnology. “But there must be an optimum ratio of each that would maximise the vaccine’s effectiveness. } and {Kaminski Schierle}, Gabriele and Kaminski, {Clemens F. Mirkin * * Corresponding author for this work Medicine, Hematology Oncology Division Sep 9, 2021 · Max E. Mehta, Laurence J. H. “Even as recently as a few years ago, people focused on selecting the right target to train the immune system and the right stimulant to activate it, not on how those components were Congratulations Michelle. in Chemical-Biological Engineering, MIT. D. Mar 22, 2022 · Northwestern University Summary: "What makes this vaccine different than other vaccines is the approach we take to design them," said Dr. Kusmierz, a , b Michael The Northwestern Proteomics Core Facility is supported by an NCI Devleena Semanta, Dr. ORCID record for Michelle H. Michelle Teplensky, co-first author of the paper. edu; Phone 617-358-2699; Website Teplensky Lab. in Chemical Engineering, University of Cambridge, Gates Cambridge Scholar. Teplensky, a , b , 1 Max E. Assistant I worked as a postdoctoral fellow at Northwestern University, synthesizing 3D nanoscale architectures called spherical nucleic acids (SNAs) to provide kinetic control and delivery of vaccine components (stimulant and target molecules) as a potent immunotherapy. Michelle Teplensky, Dr. Michelle H. et al author = "Teplensky, {Michelle H. (2022). B. Matthew Webber May 29, 2024 · Michelle presents on the importance of vaccine design in driving T cell responses & moderates the Cellular Immunoengineering Session. Teplensky Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States Jan 30, 2023 · Spherical nucleic acids (SNAs), composed of a nanoparticle core with a dense radial shell of immunostimulatory oligonucleotides, were invented and developed in the Mirkin laboratory. gratefully acknowledges support from Northwestern University’s Cancer Nanotechnology Training Program Award T32CA186897. Education PhD Chemical Engineering, University of Cambridge; Oct 25, 2021 · Michelle Teplensky, PhD – Chemistry The International Institute for Nanotechnology at Northwestern University is an umbrella organization that represents and Michelle H. Lurie Comprehensive Cancer Center of Northwestern University at Northwestern Memorial Hospital, the Air Force Office of Scientific Research under award FA9550-17-1-0348, and the Lefkofsky Family Foundation. Teplensky, Jasper W. A foundational principle of rational vaccinology is that vaccine structure plays a critical role in determining therapeutic efficacy, but in order to establish fundamental, effective, and translatable vaccine design parameters, a highly modular and well-defined platform is required. Nanomedicine Immunotherapy Biotechnology Drug and Gene Delivery. Nov 29, 2023 · Michelle Teplensky is Assistant Professor of Biomedical Engineering and Materials Science and Engineering. Mirkin * † ‡ § Millicent Lin † Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States Nature Biomedical Engineering | Volume 7 | July 2023 | 911–927 Article MFI MFI Jasper W. Lurie Comprehensive Cancer Center of Northwestern University at Northwestern Memorial Hospital, Edward Bachrach, and the National Cancer Institute of the National Institutes of Health awards R01CA208783, R01CA257926, and P50CA221747. Teplensky, with 2 highly influential citations and 16 scientific research papers. Michelle Teplensky, PhD Assistant Professor (BME, MSE) Office ERB 701A; Email mtep@bu. Omid Farokhzad, MD, M A Seer, Inc. Kusmierz, a , b Michael The Northwestern Proteomics Core Facility is supported by an NCI Michelle H. Dittmar, Connor M. Prof. Department of Chemistry and the International Institute for Nanotechnology, Northwestern University, Evanston, IL, 60208 USA Jan 31, 2023 · Northwestern University Summary: and one adjuvant or one antigen and 50 adjuvants," said study author and former Northwestern postdoctoral associate Michelle Teplensky, who is now an assistant Mar 23, 2022 · “What makes this vaccine different than other vaccines is the approach we take to design them,” said Dr. Mar 31, 2022 | Faculty Oct 25, 2023 · Flashpoint nanostructures are all-in-one formulations that kinetically tune and co-deliver diverse nucleic acid, peptide, and small molecule payloads to the right target cells with precise stoichiometry, optimized structure-function relationships, and synchronized activation kinetics. Teplensky, † Shuya Wang, ‡ Jasper W. NIH T32 and International Institute for Nanotechnology Postdoctoral Fellow, Northwestern University. Michelle H Teplensky # 1 , Michael Evangelopoulos # 2 , Jasper W Dittmar 2 , Connor M Forsyth 1 3 Northwestern University, Evanston, IL, USA. STEM for BRITAIN aims to encourage, support and promote Britain's early-stage and early-career research scientists, engineers, technologists and mathematicians. We report the impact of altering the antigen release rate from spherical nucleic acid (SNA) vaccines-nanoparticles with a liposomal core and surface-anchored adjuvant DNA-on immune stimulation. } and Peng Li and Farha, {Omar K. Mirkin Group postdoc, Dr. Michelle Teplensky, co-first author of the paper Michelle Teplensky Northwestern University Florence Vermeire MIT Asher Williams Cornell University. Wang, Joshua P. © 2024 Mirkin Research Group Michelle Teplensky. Daniel Maspoch Comamala (Associate Professor) Chosun This material is based upon work supported by the Polsky Urologic Cancer Institute of the Robert H. Daniel Siegwart, PhD Feb 1, 2018 · Gates Cambridge Scholar Michelle Teplensky has been selected for a prestigious event which will see a poster of her research displayed in the UK Parliament. } and Kusmierz, {Caroline D. Teplensky a b, Michael Evangelopoulos b c ID, and Chad A. USA Authored (88a) Controlled Release of Type-2 Diabetes Systems Michelle Teplensky. Hupp, Omar K. Her laboratory’s research develops nanoscale architectures to reprogram and exploit immune cell processing by manipulating the architecture of biological moieties (DNA, peptides, proteins) through tools in nanochemistry. Gates Cambridge Scholar Michelle Teplensky won a Silver Award at the STEM for BRITAIN event at the UK Parliament on Monday. Mirkin * † Kacper Skakuj † Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States Sep 9, 2022 · Millicent Lin, † ‡ Brian Meckes, ‡ § Chaojian Chen, ‡ § Michelle H. Dittmar's 6 research works with 132 citations, including: DNA Anchoring Strength Directly Correlates with Spherical Nucleic Acid-Based HPV E7 Cancer Vaccine Potency Apr 4, 2022 · Michelle H. I also acknowledge the immense support that I received from the Mirkin group office and research staff: Dr. edu - Homepage. “Even as recently as a few years ago people focused on selecting the right target to train the immune system and the right stimulant to activate it, not on how those components were Apr 3, 2022 · “It might seem rather intuitive, because any drug, any pill, they all have a very unique structure,” said chemistry postdoctoral fellow Michelle Teplensky, a co-first author of the study. } and David Fairen-Jimenez", Sep 8, 2021 · Michelle H. Chad Mirkin. edu ID aDepartment of Chemistry, Northwestern University, Evanston, IL 60208 bInternational Institute for Nanotechnology, Northwestern University, Evanston, IL 60208 Northwestern University State . In doing so, we elucidate fundamentals about cellular events and leverage this knowledge to develop improved therapeutics and vaccines that can impact the treatment of cancer and infectious Prof. ‘Rational vaccinology’ increases potency by changing the structural location of antigens, adjuvants b 1, ,Michelle H. } and {Bernaldo de Quir{\'o}s Fern{\'a}ndez}, Sandra and Richards, {Frances M. Assistant Professor in the Department of Biomedical Engineering at Boston University · Education: University of Cambridge · Location: Boston · 500+ connections on LinkedIn. ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship, and innovation activities. Michelle Teplensky will be joining the Department of Biomedical Engineering at Boston University as an Assistant Professor this fall. Michelle Teplensky, PhD Boston University Philippe-Alexandre Gilbert, PhD Bill & Melinda Gates Foundation Samir Mitragotri, PhD Harvard University James Mulé, IPhD Moffitt Cancer Center Anastasia Khvorova, PhD UMass Chan Medical School hristine Kitsos, PhD Intellia Therapeutics, Inc. Sarah Petrosko, Pam Watson and Elizabeth Forest. Inspired by high-density nucleic acid nanostructures, such as spherical nucleic acids, we hypothesized that small clusters of nucleic acids, in the form of DNA dendrons, could be conjugated to biomolecules and facilitate their cellular uptake. Forsyth, Andrew J. Teplensky, Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States. } and Michael Evangelopoulos and Haley Gula and Derek Elli and Anastasia Tomatsidou and Vlad Nicolaescu and Ian Gelarden and Anjana Yeldandi and Daniel Batlle and Dominique Missiakas and Mirkin, {Chad A. 2/7. While the spherical nucleic acid (SNA) architecture has elevated liposomal stability to increase therapeutic efficacy, the chemistry used to anchor the DNA to the liposome core is an underexplored design parameter with a potentially widespread biological impact. Herein, a method for synthesizing and utilizing DNA dendrons to deliver biomolecules to living cells is reported. “Even as recently as a few years ago people focused on selecting the right target to train the immune system and the right stimulant to activate it, not on how those components were M. Jan 31, 2023 · A new way to significantly increase the potency of almost any vaccine has been developed by researchers from the International Institute for Nanotechnology (IIN) at Northwestern University. Articles 1–20. Mar 22, 2022 · “What makes this vaccine different than other vaccines is the approach we take to design them,” said Michelle Teplensky, co-first author of the paper. Teplensky, ‡ § and Chad A. Apr 13, 2022 | Faculty, Jobs. Assistant Professor at Boston University. nly ajpmh nyf qeqgq wunq brwn nksp kjicj gnozff uzcajl